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Replacement of male sex steroids in men who have androgen deficiency
Produced by : Iran Hormone
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Nandrolone1cba Phenpropionate, Buy Nandrolone Phenpropionate Online
Main risks and target organs
There is no serious risk from acute poisoning, but chronic use can cause harm. The main risks are those of excessive androgens: menstrual irregularities and virilization in women and impotence, premature cardiovascular disease and prostatic hypertrophy in men. Both men and women can suffer liver damage with oral anabolic steroids containing a substituted 17-alpha-carbon. Psychiatric changes can occur during use or after cessation of these agents.
Summary of clinical effects
Acute overdosage can produce nausea and gastrointestinal upset. Chronic usage is thought to cause an increase in muscle bulk, and can cause an exageration of male characteristics and effects related to male hormones. Anabolic steroids can influence sexual function. They can also cause cardiovascular and hepatic damage. Acne and male- pattern baldness occur in both sexes; irregular menses, atrophy of the breasts, and clitoromegaly in women; and testicular atrophy and prostatic hypertrophy in men.
Diagnosis The diagnosis depends on a history of use of oral or injected anabolic steroids, together with signs of increased muscle bulk, commonly seen in ?body-builders?. Biochemical tests of liver function are often abnormal in patients who take excessive doses of oral anabolic steroids.
Laboratory analyses of urinary anabolic steroids and their metabolites can be helpful in detecting covert use of these drugs.
First aid measures and management principles
Supportive care is the only treatment necessary or appropriate for acute intoxication. Chronic (ab)users can be very reluctant to cease abuse, and may require professional help as with other drug misuse.
PHYSICO-CHEMICAL PROPERTIES
Origin of the substance
Naturally-occuring anabolic steroids are synthesised in the testis, ovary and adrenal gland from cholesterol via pregnenolone. Synthetic anabolic steroids are based on the principal male hormone testosterone, modified in one of three ways:
- alkylation of the 17-carbon
- esterification of the 17-OH group
- modification of the steroid nucleus
Physical properties
Colour: White to creamy-white
State/form: Solid-crystals
Description
Crystalline powder with a slight characteristic odour. Practically insoluble in water; soluble in alcohol.
Other characteristics
Shelf-life of the substance
Storage conditions
Store in airtight containers. Protect from light.
Vials for parenteral administration should be stored at room temperature (15 to 30?C). Visual inspection for particulate and/or discoloration is advisable.
Indications
Anabolic agent; systemic
Anabolic steroid androstan derivative; anabolic steroid
Estren derivative; anabolic steroid
Other anabolic agent
Description
The only legitimate therapeutic indications for anabolic steroids are:
(a) replacement of male sex steroids in men who have androgen deficiency, for example as a result of loss of both testes
(b) the treatment of certain rare forms of aplastic anaemia which are or may be responsive to anabolic androgens.
(c) the drugs have been used in certain countries to counteract catabolic states, for example after major trauma.
Contraindications
Known or suspected cancer of the prostate or (in men) breast.
Pregnancy or breast-feeding.
Known cardiovascular disease is a relative contraindication.
Oral
Anabolic steroids can be absorbed from the gastrointestinal tract, but many compounds undergo such extensive first-pass metabolism in the liver that they are inactive. Those compounds in which substitution of the 17- carbon protects the compound from the rapid hepatic metabolism are active orally (Murad and Haynes, 1985). There are preparations of testosterone that can be taken sublingually.
Parenteral
Intramuscular or deep subcutaneous injection is the principal route of administration of all the anabolic steroids except the 17-alpha-substituted steroids which are active orally.
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