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 | | | |  | | Heparin - 5 Vials x 5 ml (5000 IU) | | | |  | Package: 5 Vials x 5 ml (5000 IU)
Usage: Injectable
It is used to stop blood clots forming within the blood vessels
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Heparin, Buy Heparin Online
Brand names: Hep-Pak, Heparin Lock Flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage.
Generic Name: heparin (HEP a rin).
Heparin is a member of the medicine classes known as anticoagulants. A question appears: which is the action of an anticoagulant? The function of anticoagulants is to prevent coagulation; it means that anticoagulant stops blood from clotting. But anticoagulant can't diminish the size of the blood clots which have been already developed. It is essentially to mention that this medication has other functions too. The main goal of heparin is to struggle against invading bacteria and other foreign compouns.
This medicine is administrated by injection into a vein or under the skin (subcutaneously). It must not be injected into a muscle.
Structure of Heparin
Heparin is composed of a differently sulfated repeating disaccharide unit. The most general disaccharide unit is composed of a 2-O-sulfatediduronic acid and 6-O-sulfated, N-sulfated glucosamine, IdoA(2S)-GlcNS(6S). For example, this makes up 85% of heparins from beef lung and about 75% of those from porcine intestinal mucosa.
The main sugars which occur in this drug are listed below:
α-L-iduronic acid 2-sulfate;
2-deoxy-2¬sulfamino-α-D-glucose 6-sulfate;
β-D-glucuronic acid;
2-acetamido-2-deoxy-α-D¬glucose;
α-L-iduronic acid.
These sugars are present in decreasing amounts, usually in the order (2) > (1) > (4) > (3) > (5). This product is strongly acidic because of its content of covalently linked sulfate and carboxylic acid classes.
Mechanism of action of heparin
It has been already noticed that this drug stops blood from clotting. How does it work? It neutralizes thrombin. In order to neutralize thrombin this medicine links itself to the coagulation enzyme and antithrobin. The activated antithrombin inactivates thrombin and other proteases caused blood clotting. Thus, wee see that antithrombin suppresses coagulation by inactivating proteins that participate in the coagulation cascade.
Administration of Heparin
Heparin is used in case of dialysis, during extracorporeal circulation ardiopulmonary bypass for heart surgery.
This medicine is utilized to treat patients with following diseases:
peripheral occlusive disease;
thromboprophylaxis;
acute coronary syndrome;
atrial fibrillation;
deep-vein thrombosis and pulmonary embolism.
Heparin dosage
The prescribed dose of heparin henges upon some factors. The dose is henges on the coagulation test results. These tests should be performed enough frequently. The determination of coagulation time henges upon specific aspects. If this medicine is used by continous intravenous infusion, the coagulation tests should be performed approximately each 4 hours in the early stages of treatment. When the medicine is utilized periodically by intravenous injection, coagulation tests are to be performed before every injection during the early stages of treatment.
In case of deep vein Thrombosis – Prophylaxis usual the prescribed dosage is 5000 units subcutaneously each 8 to 12 hours.
Usual dose for anticoagulation during pregnancy is 5000 units under the skin every 12 hours.
Usual adult dose for thrombotic disorder is100 units/mL each 6 to 8 hours for PVC catheters and peripheral heparin locks. But when stagnant blood is observed in catheter after it was used for drug or blood administration, it is necessary to add flushes. The dose for infants that have got thrombotic disorder is 10 units each 6 to 8 hours. Child dosage in this case is 100 units/mL every 6 to 8 hours. Additional flushes must be given when stagnant blood is observed in catheter, after catheter is used for medication or blood administration.
If a patient suffers of a massive pulmonary embolism, the starting dosage may be an IV bolus of 10,000 units which are followed by 1500 units per hour.
Probable adverse results of heparin
Heparin, as any medicine can lead to unwanted effects. Many people utilizing this medicine do not have got severe negative effects. Some general adverse reactions of this product are following: swelling at injection site, bone ache, easily broken bones. Ache and lack of feeling in the arms and legs, change in color of the arms and legs, chest pain, difficult breathing, confusion, weakness on one side of the body, slurred speech, vision changes.
Heparin can cause some other unwanted reactions: signs of serious bleeding, including unusual ache, swelling, discomfort, prolonged bleeding from cuts, continous nosebleeds, unusually heavy and long-term menstrual periods, unusual easy bruising, dark urine, black stools, severe headache, unusual dizziness.
Severe allergic symptoms were registered rarely, but sometimes they can be caused. If you use this medicine and observe such consequences as rash, itching, swelling, severe dizziness, difficult breathing and others, call your pharmacist.
There are such undesirable reactions that are caused in case of long-term Heparin administration; others can be results of a systematic using of this medication. For example, osteoporosis may be caused by long-term utilizing of high doses of this medicine, cutaneous necrosis has been noticed after systemic using; suppression of aldosterone synthesis, delayed transient alopecia, priapism, and rebound hyperlipemia on discontinuation of this medicine have also been reported.
Important elevations of aminotransferase grades have occurred in a high percentage of patients and healthy persons that have received this preparation.
Coumadin and Heparin
Coumadin and Heparin are anticoagulants, so they both stop blood from clotting. They are administrated to treat such conditions as embolism and thrombosis. However they sound similar, coumadin and heparin have got a lot of differences. As for utilizing them, coumadin is used orally, heparin is usedin a form of injection. Coumadin must not be administrated during pregnancy, heparin may be administrated during pregnancy. They both can lead to excessive bleeding that may be fatal.
Heparin recall
Firstly, let notice what medication recalls are. Drug recalls are such acts that are taken in order to remove some medications from the market.
As for Heparin, the most of recalls were in 2008 as a result of negative consequences of heparin that was manufactured in China.
But there were no any recalls related to heparin which was manufactured by B. Braun Medical Inc. B.Braun manufacturer recommends to stop heparin use and consult your prescriber, if any unwanted consequences occur.
Heparin-induced thrombocytopenia
Heparin-induced thrombocytopenia (HIT) is a form of thrombocytopenia that was caused by using of heparin. Thus, it is a side effect which was caused by heparin use. There are two types of heparin-induced thrombocytopenia: type 1 and type 2. HIT type 2 is a more serious adverse reaction than HIT type 2. HIT type 2 can be a life-threatening aspect. In order to be sure that a person has HIT, he should do specific laboratory tests. Buy Heparin - 5 Vials x 5 ml (5000 IU) online at our shop
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