Posts Tagged ‘methandrostenolone’

Methandrostenolone

Wednesday, January 16th, 2008

Methandrostenolone (Dianabol)

is an anabolic steroid originally developed by John Ziegler and released in the US in 1956 by Ciba. It was used as an aid to muscle growth by bodybuilders until its ban by the FDA under the Controlled Substances Act. Despite this, methandrostenolone continues to be produced in countries such as Mexico under the trade name Reforvit-b, and is being manufactured in Russia, as well as Thailand, and subsequently is still seen on the United States black market. production in most of Western Europe and the United States has ceased.

Several successful athletes and professional bodybuilders have come forward and admitted long-term methandrostenolone use, including Arnold Schwarzenegger [1] and Sergio Oliva [2]. Despite its illegality many athletes continue to use the drug for the muscle mass gains it can cause.

Methandrostenolone does not react strongly with the androgen receptor, instead relying on activity not mediated by the receptor for its effects. These include dramatic increases in protein synthesis, glycogenolysis, and muscle strength over a short space of time. However, due to its mode of action, it decreases the rate of cell respiration and decreases production of red blood cells. In high doses (30 mg or more per day), side effects such as gynaecomastia, high blood pressure, acne and male pattern baldness may begin to occur. The drug causes severe masculinising effects in women even at low doses. In addition, it is metabolised into estradiol by aromatase. This means that without the administration of aromatase inhibitors such as Anastrozole or Aminoglutethimide, estrogenic effects will appear over time in men. Many users will combat the estrogenic side effects with Nolvadex or Clomid. In addition, as with other 17?-alkylated steroids, the use of methandrostenolone over extended periods of time can result in liver damage without appropriate care.

In the early 1960s, doctors commonly prescribed a tablet per day for women as a tonic. This use was quickly discontinued upon discovery of the heavily masculinising effects of methandrostenolone. However, despite the lack of any known therapeutic applications, the drug remained legal until the early 1990s. The ban by the FDA was not completely successful in eliminating its use by bodybuilders, and methandrostenolone continues to be used illegally to this day, typically being stacked (combined) with Drugs that react strongly with the androgen receptor, such as Oxandrolone, in order to increase the overall effectiveness of steroid use.

The 17?-methylation of the steroid does allow it to pass through the liver without being broken down (hence causing the aforementioned damage to the liver) allowing it to be taken orally. It also has the effect of decreasing the steroid’s affinity for sex hormone binding globulin, a protein that de-activates steroid molecules and prevents them from further reactions with the body. As a result, methandrostenolone is significantly more active than an equivalent quantity of testosterone, resulting in rapid growth of muscle tissue. However, the concomitant elevation in estrogen levels - a result of the aromatization of methandrostenolone - results in significant water retention. This gives the appearance of great gains in mass and strength, which prove to be temporary once the steroid is discontinued and water weight drops. Because of this, it is often used by bodybuilders only at the start of a “steroid cycle”, to facilitate rapid strength increases and the appearance of great size, while compounds such as testosterone or nandrolone with long acting esters build up in the body to an appreciable amount capable of supporting anabolic function on their own.

Types of Steroids

Monday, January 7th, 2008

Below we’ve compiled a list of some anabolic steroids, including their relative potency and some other info. Sometimes, the names of steroids can be confusing to a newbie. This is because you have the chemical name, the various brand names, and the slang or street names for each product.
For example, methandrostenolone is known to most people as Dianabol, but you probably hear it referred to as D-bol. Of course, you’ll likely be using the veterinary version called Reforvit-B, whose street name is Reffie or Reffie-B. Got all that? Don’t worry, the more you read the more you get used to all the terminology. To help you out, I’ve listed the chemical name as well as a few of the trade names for each ‘roid.

Fluoxymesterone (Halotestin, Stenox)
This is a 17-alpha alkylated steroid. In other words, it’s been altered in order to withstand the liver’s “first pass” metabolism to a better degree, i.e., the liver doesn’t inactivate the stuff before it can exert its effects. Without this alkylation, you’d need much higher concentrations to get results, as is the case with any 17-AA. Anyhow, this steroid appears to have a lower affinity for the AR, but can agonize the receptor at higher dosages.
As far as “real world” effects, fluoxymesterone has a reputation for increasing strength to a large degree. However, gains in muscle mass on this steroid aren’t very great. In clinical settings, dosages range from 2.5 mg to 40 mg a day in divided dosages. However, bodybuilders have been known to use from 30 to 80 mg per day. It has a half-life of approximately 9.2 to 10 hours. (I’ll talk about why knowing about half-lives is important later.) Oh yeah, and it doesn’t aromatize. This means it’s not likely to convert to estrogen, the female hormone. In the real world, that means the risk getting gyno (••••• tits, i.e. breast tissue growth in males) is small to nonexistent.

Methandrostenolone (Dianabol, Reforvit, Anabol)
This 17-AA steroid was the first to be introduced to athletes in the 50s. Bodybuilders caught on soon after, no doubt. It’s aromatizable, and therefore can increase estrogen levels. Since it doesn’t bind very well to the AR, it’s thought that it works by antagonizing the effects of catabolic glucocorticoids.
D-bol has a great reputation for increasing both size and strength to a pretty good degree. While the half life isn’t readily available in the literature, it can be assumed through deductive reasoning that it’s around four to seven hours. Bodybuilders typically use around 25 to 100 mg per day depending on whether it’s used alone or in conjunction with another steroid (a practice called stacking).

Stanozolol (Winstrol)This steroid is also17-AA. It can’t aromatize and doesn’t bind very well to the AR. Consequently, it’s likely to exert its anabolic effects in a similar fashion to that of methandrostenolone. In other words, it affects glucocorticoids in a beneficial manner.
Another benefit may be its ability to antagonize or block progesterone from binding to receptors. Progesterone is one of the reasons why certain anabolics cause water retention.
Stanozolol has a great reputation for increases in strength as well as moderate increases in muscle mass. Actually, these “moderate” gains are rather impressive, considering that this drug doesn’t cause much water retention. In clinical settings, typical dosages are between 2 to 6 mg daily. In order to see desired effects, bodybuilders typically consume between 25 to 100 mg daily. While I can’t locate any literature on its half-life, based on its molecular composition it would seem to have a slightly longer half-life than most of the other orals. I’d say it’s likely to be in the range of 7 to15 hours.

Oxandrolone (sold as oxandrolone powder or Oxandrolona)
This is yet another 17-AA. It won’t aromatize but appears as though it will bind to the AR as long as the dosages are high enough. It has a reputation for increasing strength gains, as well as having a “hardening” effect. This is supported somewhat, as oxandrolone was shown to reduce subcutaneous fat to a greater degree than Testosterone. Whether this is an inherent property of all 17-AA steroids or an effect that’s unique to oxandrolone, I’m not sure.
Oxandrolone, along with most of the other synthetic steroids, are thought to be equally (if not more) anabolic than Testosterone on a milligram per milligram basis, while minimizing androgenic side effects. Oxandrolone was shown to have approximately six times the anabolic effect of methyltestosterone in human subjects, following oral doses. Oxandrolone may also increase the number of skeletal muscle androgen receptors.
In clinical settings, dosages have ranged from 1.25 to 80 mg per day. Bodybuilders may take anywhere from 25 to 160 mg per day. The half-life is approximately nine hours.

Methenolone Acetate and Enanthate (Primobolan)
This steroid doesn’t aromatize and can either be ingested via the acetate version or injected via the enanthate. This steroid does bind rather well to the AR and is known for its mild gains in muscle mass. Still, considering that it’ll cause next to zero water retention, these gains are rather good. (Note that some bodybuilders think certain steroids work better based solely on the weight they gain. In actuality, they could be just retaining a lot of water along with the muscle gains. These are the same guys who think they “lose” a lot of muscle after their cycle is completed, when they actually just lost much of the water they’d been holding.)
Clinical dosages that are commonly seen with methenolone range from 10 to 20 mg daily, sometimes a little higher for the oral version. For the enanthate version, dosages are usually 100 mg every two to four weeks. Bodybuilders typically use 400 to 1000 mg a week. The half-life appears to be very similar to Deca, perhaps slightly shorter. So with this in mind, I’d say the half-life would be around five to seven days.

Oxymetholone (Anadrol)
This 17-AA steroid can’t aromatize, but has been known to have progestenic properties and thus, can cause water retention. It has a great reputation for increasing muscle mass and strength to a large degree. It’s also thought to have a very high anabolic/androgenic ratio.
The typical dosage in clinical settings is one to five milligrams per kilogram of bodyweight per day. So, a 150 pound person would consume anywhere from 68 to 341 mg per day. However, the higher dosages aren’t employed that often. Bodybuilders typically consume around 50 to 150 mg per day. While I can’t find info on the half-life in the formal literature, it would seem it’s similar to that of stanozolol. Obviously, this isn’t a hard fact, but the half-life should be right in the neighborhood of 7 to15 hours. Only God and Bill Roberts know for sure.
Testosterone Enanthate, Cypionate, Propionate, Suspension (commonly called “T”)
This steroid can aromatize and binds well to the AR. It’s well known for its ability to produce great gains in muscle size and strength, provided that the dosages are high enough. It does cause quite a bit of water retention and has quite a few side effects when compared to the other anabolics.
Clinical dosages vary, but cypionate and enanthate are both injected every two to three weeks at dosages of around 200 to 300 mg. Propionate and suspension aren’t preferred as they don’t provide that long of a sustained release. Bodybuilders typically use around 500 to 1,000 mg per week. The cypionate ester has a half-life of around eight days. Enanthate is just slightly shorter and propionate is quite a bit shorter. By the way, Testosterone in a suspension has a half-life of only 10 to 100 minutes.

Nandrolone Decanoate and Laurate (usually referred to as Deca)
This steroid binds very well to the AR and doesn’t aromatize. It can produce moderate gains in muscle mass with little water retention. However, it, like oxymetholone, can be progestenic leading to water retention when higher dosages are used.
In clinical settings, dosages are around 50 to 100 mg every three to four weeks. Bodybuilders use around 300 to 800 mg per week. The decanoate ester has a half-life of six to eight days and the laurate ester commonly seen in veterinary products has a slightly longer half-life.
How to Construct a Cycle The dosages should be determined after evaluating two things: one, what results you’d like to see and two, which drugs you’re stacking. There are other factors to consider, but for the sake of simplicity we’ll stick with these two for now.
Regardless of what type of results you’re looking for, it would be wise to stack two drugs that work through different mechanisms in order to get a synergistic effect. For instance, you’d get better results by stacking nandrolone with stanozolol as opposed to nandrolone and oxandrolone. This is because nandrolone and oxandrolone both bind to the AR. I’ve given you a few examples of stacks below. I’ll give a quick review afterward.

Stack 1: Nandrolone, 450 mg per week along with 50 mg per day of stanozolol

Stack 2: Nandrolone, 450 mg per week along with 50 mg per day of methandrostenolone

Stack 3: Oxandrolone, 40 mg per day along with 50 mg per day of stanozolol

Stack 4: Testosterone enanthate, 500 mg per week along with 50 mg stanozolol or methandrostenolone per day

Stack 5: Testosterone or nandrolone, 500 mg per week with 50 mg oxymetholone per day

Stack 6: Methenolone, 600 mg per week with 50 mg per day stanozolol

Let’s take a closer look at the first stack. You’d inject 450 mg on day one and then six to eight days later another 450 mg and so on. The stanozolol (or any oral) would yield the best results when spread out as evenly as possible in order to allow the drug to remain in the bloodstream throughout the day.
Also, by knowing the half-lives of drugs, you can figure out, to an approximate level, how much of the drug is currently active in your body. So, if on day one you injected 450 mg, then on day seven or eight you should have around 225 mg that’s still active. When you inject another 450 mg, you then have approximately 675 mg of nandrolone in your body at that moment. However, that number then begins to slowly decline in an instant. By simply applying the half-life, you can figure out just how much of the drug is still in your bloodstream.
As a quick note, half-lives can vary depending on a number of factors, and this is why most texts give you a range, like four to nine hours. One such thing is the size of the person. Generally speaking, the larger the body mass of the person, the shorter the half-life is going to be. While some guys will only ingest oral steroids on the days that they work out, you don’t necessarily have to do this. Remember, you’re recovering on those off days, so why not help accelerate the process?
The oxandrolone and stanozolol stack above (#3) would be for those who are “needle phobic.” However, this particular stack shouldn’t be used for too long, because the 17-AA are the steroids that are most associated with liver damage.
As far as how long to stay “on” and how long to go “off,” here’s my take: It really depends on what your goals are. I mean, if you want to gain 35 pounds in two months, then chances are you won’t be able to cycle off and still attain that goal. If, however, you’re keeping safety in mind and would only like to gain something like eight to twelve pounds, then a two to three week “on,” followed for four to six weeks “off” cycle will suffice